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In a game littered with notable injuries, the Los Angeles Rams host the San Francisco 49ers on Sunday afternoon. Los Angeles (0-2) enters off a 41-10 blowout loss to Arizona and without top wide receivers Cooper Kupp and Puka Nacua, as well as several key offensive linemen. San Francisco (1-1) lost in Minnesota last Sunday, 23-17, and will be without Christian McCaffrey, Deebo Samuel and George Kittle. The teams split a pair of meetings last season with the road team winning each time.
While it's still so obviously early in the season, Week 3's NFC West showdown between the San Francisco 49ers and Los Angeles Rams feels like a must-win game for both squads. For the 1-1 Niners, it's a get-right game after losing in disjointed fashion a week ago to the Minnesota Vikings. Considering San Francisco is aiming for nothing short of a Super Bowl victory this season, falling behind early in the NFC standings would be disastrous.
Meanwhile for a depleted and winless LA squad, desperation may already be settling in unless head coach Sean McVay wants to chalk up 2024 as a lost campaign. McVay's Rams have defeated the 49ers in only four regular-season games dating back to 2017, meaning head coach Kyle Shanahan and Co. still have something of a historical edge despite dealing with their own notable injuries.
Still, divisional games get weird, and Sunday's tilt won't necessarily show each team's positive and negative trends the same way. For fans who watch live, either on television/streaming or physically going to SoFI Stadium, it's one thing. For those who wish to tune into the radio broadcast, we've got you covered.
Sunday's contest kicks off on Sept. 22 at 4:25 p.m. ET from SoFI Stadium in Inglewood, California. It's not a nationally televised game, meaning regional fans will only be able to watch the TV broadcast in specific areas. Fans can also check out the greater Niners radio network for ways to listen to Greg Papa and Tim Ryan call the game:
Related story: 49ers fans expected to take over Rams home venue (again) in Week 3
For those wishing to tune into the Rams' Los Angeles-area broadcast, ESPN 710 AM will have coverage with J.B. Long and Maurice Jones-Drew calling the game. Fans outside the two markets can listen in via Sports USA radio where John Ahlers and former San Francisco center Alex Mack will call the contest. NFL+ subscribers can also stream a live radio broadcast of Week 3's contest.
If there was any lesson to be taken from Week 2 of the NFL season for two of the top teams in the NFC West, it's that they perhaps aren't quite the powerhouses they think they are: After starting their year with a dominant Week 1 win over the New York Jets, the San Francisco 49ers were humbled by the Minnesota Vikings in Week 2. With the emergence of the Vikings defense and quarterback Sam Darnold -- himself a former 49er -- served as an early season heat check to the Niners' ambitions of getting back to the Super Bowl. But if the 49ers were humbled, the Los Angeles Rams were outright humiliated, with the Arizona Cardinals drubbing them, 41-10, and leaving them battered, bruised, and suffering from a rash of injuries at 0-2.
Now, the Rams and head coach Sean McVay will have to try and stave off an 0-3 start against a San Francisco team that might be just as hobbled. Running back Christian McCaffrey and wide receiver Deebo Samuel will be out with leg injuries, yet the Niners will still try to prove that, despite the losses, they are, in fact, one of the teams to beat in the NFC.
San Francisco is a big 7.5-point favorite against Los Angeles, according to the latest NFL odds. The over/under is 43 points. See NFL picks for every single game, including this one, from SportsLine's advanced computer model. Get picks now. The 49ers have had the upper hand in their division rivalry against the Rams, as they have won eight out of their last 10 games against Los Angeles. However, one of those games was a big one -- the 2021 NFC Championship Game, which the Rams won en route to winning Super Bowl LVI.