Teri Garr, the Oscar-nominated comedic actor best known for her spirited performances in classics such as "Young Frankenstein," "Close Encounters of the Third Kind" and "Tootsie," died Tuesday in Los Angeles, according to her publicist and friend Heidi Schaeffer.

She was 79. The cause of death was complications from multiple sclerosis, Schaeffer said.

Garr was open about her experience with MS, a health ordeal she chronicled in the 2005 autobiography "Speedbumps: Flooring it Through Hollywood."

In a screen career that spanned more than 40 years, Garr endeared herself to audiences with her quirky on-screen persona and quick wit. She was a familiar face on sitcoms and late-night talk shows, including NBC's "The Tonight Show" during the Johnny Carson era.

Garr, who was trained as a ballet performer, launched her Hollywood career as a uncredited go-go dancer in six musicals starring Elvis Presley.

In the early 1970s, Garr pivoted to more substantive acting roles and collaborated with some of the leading filmmakers of the decade.

A Breakthrough Year

The year 1974 was pivotal: Garr delivered a supporting turn in Francis Ford Coppola's "The Conversation" and played Gene Wilder's German-accented assistant Inga in Mel Brooks' "Young Frankenstein," a black-and-white spoof of Hollywood horror flicks.

Garr's profile rose further after Steven Spielberg cast her as Richard Dreyfuss' wife in the science fiction landmark "Close Encounters." Garr's character watches in bewilderment as her husband becomes increasingly fixated on UFOs.

Oscar Recognition

Sydney Pollack's "Tootsie" brought Garr an Oscar nomination for best supporting actress. She played a neurotic acting student whose heart is broken by Dustin Hoffman's character, a struggling artist who disguises himself as a woman to land a part on a soap opera.

Garr also teamed up with Martin Scorsese ("After Hours") and Robert Altman ("Prêt-à-Porter"); Coppola made her the center of the surrealist 1982 musical "One from the Heart," a box-office disaster that contemporary critics have positively reappraised.

From Big Screen to Sitcom

Younger viewers may be more familiar with Garr thanks to her role opposite Michael Keaton in "Mr. Mom" as well as her recurring role on the NBC sitcom "Friends" as Lisa Kudrow's estranged mother.

Teri Ann Garr was born on Dec. 11, 1944 in Ohio; her father was a vaudeville performer and her mother was a dancer. The family eventually settled in the Los Angeles area, where Garr's father died of a heart attack when she was young. Garr trained in the art of ballet before heading to New York City to try her hand at acting.

She landed her first speaking role in 1968's "Head," a kooky satirical musical starring The Monkees and written by Jack Nicholson. 

Early Television Work

Garr's early small-screen work included appearances on the 1960s incarnation of "Batman," an episode of the original "Star Trek" and the variety show "The Sonny and Cher Comedy Hour."

"I was always hustling for the next job," Garr wrote in her autobiography.

Garr's doggedness paid off, and she remained prolific all through her screen career. Pauline Kael, the legendary film critic for The New Yorker, once hailed Garr as "perhaps the funniest, most neurotic dizzy dame on the screen."

Advocacy for MS

Garr went public with her multiple sclerosis diagnosis on national television in October 2002. She later became a key advocate for MS awareness, traveling across the country to speak with doctors and patients about her experiences.

"I think everybody is scared and frightened when they hear something like that," Garr told CNN in 2002. "That’s because there’s so much — you know, there’s not a lot of information out there about it. And a lot of people don’t know that it’s not that bad. I mean, I’m going on with my life."

In late 2006, Garr suffered a brain aneurysm that changed her speech and motor skills.

She retired from acting in 2011, but her legacy continued to loom over the comedy world, inspiring younger female comedians.

"The person I always think of is Teri Garr," Tina Fey was once quoted as saying. "There was a time when Teri Garr was in everything. She was adorable, but also very real. Her body was real, her teeth were real, and you thought that she could be your friend."

A Lasting Legacy

Garr may be "an overlooked comic genius by so many generations," Kessler says. "If you were not around and paying attention to what she was doing in the '70s and the '80s, then you missed it."

Garr's comedic timing and ability to play off of her comedic partners, like Gene Wilder in "Young Frankenstein" and Dustin Hoffman in "Tootsie," made her a beloved figure in Hollywood. She was known for her vulnerability and warmth, making audiences fall in love with her characters. While she may have been overlooked by some, her contributions to the entertainment industry are undeniable. She was a talented performer, an advocate for people with MS, and a kind and generous person. Her legacy will live on in her work and in the hearts of those who knew her. She will be missed.