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Ozempic and Wegovy: New Study Raises Concerns About Suicidal Thoughts

24 August, 2024 - 8:09AM
Ozempic and Wegovy: New Study Raises Concerns About Suicidal Thoughts
Credit: img-s-msn-com.akamaized.net

Ozempic and Wegovy: New Study Finds Potential Link to Suicidal Thoughts

The use of semaglutide, the popular medication for diabetes and weight loss, has surged in recent years. Sold under the brand names Ozempic (for diabetes) and Wegovy (for weight loss), semaglutide has shown promising effects, including reductions in kidney disease and cancer. However, a new study published in the journal JAMA Network Open has raised concerns about a potential link between semaglutide and suicidal thoughts.

The study, which analyzed data from a World Health Organization database that tracks suspected adverse drug reactions, found a 45% greater rate of reports of suicidal thoughts associated with semaglutide compared with all other drugs in the database.

Concerns About the Study's Methodology

While the study's findings have sparked concern, experts have raised questions about the study's methodology. Critics argue that the study's design makes it difficult to definitively conclude that semaglutide is causing suicidal thoughts. The study relied on a disproportionality analysis, which compares the number of reports of a specific adverse event with the number of reports for all other drugs. This method can help identify potential signals of safety concerns, but it doesn't prove cause and effect.

“Basically, it is hard to tease out from this study whether it is the drug doing this or the mood disorder,” said Dr. Mahyar Etminan, an expert in drug safety at the University of British Columbia in Vancouver who was not involved in the study.

“This paper presents, at best, weak evidence of an association between semaglutide and suicidality,” said Ian Douglas, a professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine.

Conflicting Evidence and Ongoing Research

The new study's findings contradict previous research that has found no link between semaglutide and suicidal thoughts. In fact, a large study published earlier this year in the journal Nature Medicine found that use of semaglutide was linked to a lower risk of suicidal thoughts compared with people taking different kinds of medications for weight loss and diabetes.

The European Medicines Agency (EMA) has also been investigating the risk of suicide and suicidal thoughts across drugs in the same class as semaglutide, and thus far has not found any increased risk. The U.S. Food and Drug Administration (FDA) is also conducting similar investigations.

Importance of Caution and Further Research

Despite the conflicting evidence, the study's authors believe their findings warrant further study and “urgent clarification” about the risk of suicidal thoughts associated with semaglutide. They emphasize the need for caution in prescribing GLP-1 medications, especially to patients with a history of depression or suicidal thoughts.

“Depression or suicidality are rare but extremely severe events and need to be prevented and managed as much as possible,” wrote Dr. Francesco Salvo and Dr. Jean-Luc Faillie, two French drug safety researchers who were not involved in the research.

The authors of the study also recommend that patients taking semaglutide be carefully monitored for any changes in mood or behavior. If patients experience a new episode of depression while on the medication, doctors may want to consider “immediate discontinuation.”

What This Means for Patients

While this new study has raised concerns about a potential link between semaglutide and suicidal thoughts, it's important to remember that the relationship is not yet definitively proven. The study's findings are a signal for further research, and it's crucial to consider them in the context of previous research and ongoing investigations.

If you are taking semaglutide and experience any changes in mood or behavior, it's essential to speak with your doctor immediately. It's also crucial to seek professional help if you or someone you know is struggling with suicidal thoughts. You can reach the 988 Suicide & Crisis Lifeline by dialing 988 to connect with a trained counselor, or visit the 988 Lifeline website.

A Deeper Dive into the Drug's Potential Effects

The latest study has sparked debate about the potential mental health risks associated with semaglutide. While some experts call for caution and further research, others believe the study's findings are inconclusive and require a more nuanced understanding of the data.

The study's authors argue that their findings are particularly concerning for people with anxiety and depressive disorders, suggesting these individuals may be at a higher risk of reporting suicidal ideation when medicated with semaglutide. This finding underscores the importance of considering a patient's mental health history when prescribing GLP-1 medications.

Looking Forward

As semaglutide continues to gain popularity, it's essential to remain vigilant about its potential side effects. While the current evidence is inconclusive, this new study highlights the need for further research to better understand the complex relationship between semaglutide and mental health. In the meantime, patients taking GLP-1 medications should be aware of the potential risks and discuss any concerns with their doctor.

Ozempic and Wegovy: New Study Raises Concerns About Suicidal Thoughts
Credit: nyt.com
Ozempic and Wegovy: New Study Raises Concerns About Suicidal Thoughts
Credit: forbes.com
Tags:
Semaglutide GLP-1 receptor agonist Suicidal ideation Weight loss Anti-obesity medication Novo Nordisk Ozempic Wegovy semaglutide suicidal thoughts GLP-1 Diabetes Obesity weight loss
Kwame Osei
Kwame Osei

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